a) Macromolecular therapeutics by high throughput synthesis:
Increasingly, new drug leads are arising from biomolecules (such as proteins, antibodies, and cytokines), because their size and complex structure enables them to communicate with cells in a way that small molecules are not able to. We are using a high throughput polymerisation method established in our lab to make synthetic mimics of proteins (called TRAIL) that can control cell fate by clustering protein receptors on their surface. Our technology enables the rapid generation of polymer libraries in very small volumes, and the screening of their biological activity. This project will involve high throughput polymer synthesis at UoN and collaboration with a PhD student based at UNSW for biological screening.